Publications
Incidental Detection of Elastofibroma Dorsi With 68Ga-FAPI-46 and 18F-FDG PET/CT in a Patient With Esophageal Cancer
Artineh Hayrapetian 1, Mark D Girgis, Jane Yanagawa, Samuel W French, Heinrich R Schelbert 1, Martin S Auerbach 1, Johannes Czernin, Jeremie Calais Abstract: A 71-year-old man underwent 18F-FDG and 68Ga-FAPI-46 PET/CT for initial staging prior to surgery of a squamous cell carcinoma of the lower esophagus under the prospective study NCT04147494. Both scans showed [...]
Targeting Fibroblast Activation Protein: Radiosynthesis and Preclinical Evaluation of an 18 F-Labeled FAP Inhibitor
Johannes Toms 1, Jürgen Kogler 1, Simone Maschauer 1, Christoph Daniel 2, Christian Schmidkonz 3, Torsten Kuwert 3, Olaf Prante 4 3 Fibroblast activation protein (FAP) has emerged as an interesting molecular target used in the imaging and therapy of various types of cancers. 68Ga-labeled chelator-linked FAP inhibitors (FAPIs) have been successfully applied to PET imaging of various tumor [...]
Disentangling inflammatory from fibrotic disease activity by fibroblast activation protein imaging
Christian Schmidkonz 1, Simon Rauber 2, Armin Atzinger 1, Rahul Agarwal 2, Theresa Ida Götz 1, Alina Soare 2, Michael Cordes 1, Olaf Prante 1, Christina Bergmann 2, Arnd Kleyer 2, Philipp Ritt 1, Simone Maschauer 1, Peter Hennig 1, Johannes Toms 1, Markus Köhner 1, Bernhard Manger 2, John H Stone 3, Uwe Haberkorn 4, Tobias Baeuerle 5, Jörg H W Distler 2, Abbas Agaimy 6, Torsten Kuwert 1, Georg Schett 2, Andreas Ramming 7 Objectives: To date, there is no valuable tool to assess fibrotic disease activity in humans in [...]
Fibroblast activation protein inhibitor (FAPI) PET for diagnostics and advanced targeted radiotherapy in head and neck cancers?
Patrick Conen 1 2, Felix M Mottaghy 3 4 5 Purpose: Cancer-associated fibroblasts (CAFs) expressing fibroblast activation protein (FAP) have been associated with the aggressive nature of head and neck cancers (HNCs). These tumours grow diffusely, leading to extremely challenging differentiation between tumour and healthy tissue. This analysis aims to introduce [...]
68Ga-FAPI PET/CT in Assessment of Liver Nodules in a Cirrhotic Patient
Liang Zhao 1, Jianwei Gu 2, Kaili Fu 1, Qin Lin 1, Haojun Chen 2 Abstract: Ga-FAPI PET/CT was performed in a 56-year-old cirrhotic patient with multiple liver nodules, which were suspected of hepatocellular carcinoma by contrast-enhanced magnetic resonance but were not visualized by F-FDG PET/CT. Increased Ga-FAPI liver uptake was observed in [...]
[ 68 Ga]Ga-DOTA-FAPI-04 and [ 18 F] FDG PET/CT for the diagnosis of primary and metastatic lesions in patients with hepatic cancer
Jieling Zheng 1, Shaobo Yao 2 Article available for purchase or this subscription. Affiliations: Department of Nuclear Medicine, The First Affliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Fuzhou, 350005, Fujian Province, China. Department of Nuclear Medicine, The First Affliated Hospital of Fujian Medical University, [...]