PUBLICATIONS
![[68Ga]Ga-FAPI-46 PET accuracy for cancer imaging with histopathology validation: a single-centre, single-arm, interventional, phase 2 trial](https://sofie.com/wp-content/uploads/2025/09/image.png)
[68Ga]Ga-API-46 PET accuracy for cancer imaging with histopathology validation: a single-centre, single-arm, interventional, phase 2 trial
Kim M Pabst, Manuel M Weber, Christina Laschinsky, Patrick Sandach, Timo Bartel, Alina T Küper, Lukas Kessler, Marija Trajkovic-Arsic, Markus Eckstein, Elena Gilman, Michael Nader, Francesco Barbato, Lars E Podleska, Boris A Hadaschik, Rainer Hamacher, David Kersting, Nicola von Ostau, Bastian von Tresckow, Hans-Peter [...]
90 Y-FAPI-46 Theranostics Leads to Near-Complete Metabolic Response in 3 Patients with Solitary Fibrous Tumors
Helena Lanzafame, Christoph E Heilig, Eva Wardelmann, Mélanie Desaulniers, Kim Magaly Pabst, Ilektra Antonia Mavroeidi, Ina Pretzell, Pedro Fragoso Costa, Micheal Nader, Stephan Leyser, Martin Schuler, Sebastian Bauer, Jens Thomas Siveke, Leila Kamkar, Simon Kreutzfeldt, Stefan Fröhling, Sebastian Mühl, Ken Herrmann, Wolfgang Peter Fendler, [...]
Early image acquisition 68Ga-FAPI-46-PET/CT in prone position is promising in the workup of rectosigmoid and anal carcinoma
D Ufton, J Heilinger, H Weis, T Fischer, K Schomäcker, C Bruns, G Dieplinger, H Dapper, E Fokas, C Kobe, A Drzezga, S Ferdinandus, K S Roth Abstract: Purpose: To overcome difficulties with regard to anatomic discrimination of intrapelvic tumors and non-specific intrapelvic uptake (i.e. [...]
Efficacy of [68Ga]Ga-FAPI-PET as a non-invasive evaluation method of liver fibrosis
Yuriko Mori, Katharina Tamburini, Emil Novruzov, Dominik Schmitt, Eleni Mavriopoulou, Sven H Loosen, Christoph Roderburg, Tadashi Watabe, Clemens Kratochwil, Manuel Röhrich, Abass Alavi, Uwe Haberkorn, Frederik L Giesel Abstract: Introduction: Liver fibrosis is a chronic fibrosing hepatic disorder following recurrent injury, characterized by the excessive [...]
![Comparison of [99mTc]Tc-FAPI SPECT/CT and [18F]FDG PET/CT as predictive biomarkers for immunotherapy response in gastrointestinal cancer](https://sofie.com/wp-content/uploads/2025/06/info.ibamolecular.jpg)
Comparison of [99mTc]Tc-FAPI SPECT/CT and [18F]FDG PET/CT as predictive biomarkers for immunotherapy response in gastrointestinal cancer
Yu Zhang, Hong Chen, Dajia Lin, Zhiyi Lin, Jiyun Shi, Hannan Gao, Chenshen Huang, Fangqing Xue, Fan Wang, Wenxin Chen Abstract: To explore the diagnostic performance of [99mTc]Tc-FAPI SPECT/CT for gastrointestinal cancer, compared to [18F]FDG PET/CT. In this analysis of a prospective trial, consecutively [...]
Spatial FAP Expression as Detected by 68 Ga-FAPI-46 Identifies Myofibroblasts Beyond the Infarct Scar After Reperfusion
Annika Hess, Alexandra Renko, Andreas Schäfer, Mira Jung, Daniela Fraccarollo, Jan D Schmitto, Johanna Diekmann, Thomas Thum, Frank M Bengel, Johann Bauersachs, James T Thackeray, Jochen Tillmanns Abstract: Purpose: Myocardial infarction (MI) triggers complex cellular responses essential for tissue repair and remodeling, including myofibroblast [...]
Head-to-head comparison of 18F-FDG and 68Ga-FAPI PET/CT in common gynecological malignancies
Tengfei Li, Jintao Zhang, Yuanzhuo Yan, Yue Zhang, Wenjie Pei, Qingchu Hua, Yue Chen Abstract: Background: 68Ga-FAPI (fibroblast activation protein inhibitor) is a novel and highly promising radiotracer for PET/CT imaging. It has shown significant tumor uptake and high sensitivity in lesion detection across [...]
Discrimination between Inflammatory and Fibrotic Activity in Crohn’s Disease-Associated Ileal-Colonic Anastomotic Strictures by Combined Ga-68-FAPI-46 and F-18-FDG-PET/CT Imaging GalleryDiscrimination between Inflammatory and Fibrotic Activity in Crohn’s Disease-Associated Ileal-Colonic Anastomotic Strictures by Combined Ga-68-FAPI-46 and F-18-FDG-PET/CT Imaging
Discrimination between Inflammatory and Fibrotic Activity in Crohn’s Disease-Associated Ileal-Colonic Anastomotic Strictures by Combined Ga-68-FAPI-46 and F-18-FDG-PET/CT Imaging
Michael Beck, Torsten Kuwert, Armin Atzinger, Maximilian Gerner, Arndt Hartmann, Marc Saake, Michael Uder, Markus Friedrich Neurath, Raja Atreya Abstract: Introduction: The development of an intestinal stricture in patients with Crohn's disease represents an important and frequent complication, reflecting the progressive nature of the disease. [...]
Feasibility, Tolerability, and Preliminary Clinical Response of Fractionated Radiopharmaceutical Therapy with 213Bi-FAPI-46: Pilot Experience in Patients with End-Stage, Progressive Metastatic Tumors GalleryFeasibility, Tolerability, and Preliminary Clinical Response of Fractionated Radiopharmaceutical Therapy with 213Bi-FAPI-46: Pilot Experience in Patients with End-Stage, Progressive Metastatic Tumors
Feasibility, Tolerability, and Preliminary Clinical Response of Fractionated Radiopharmaceutical Therapy with 213Bi-FAPI-46: Pilot Experience in Patients with End-Stage, Progressive Metastatic Tumors
Andreas Helisch, Clemens Kratochwil, Christian Kleist, Susanne Krämer, Juan Jose Rosales Castillo, Katharina Dendl, Hendrik Rathke, Isabelle von Goetze, Mathias Schreckenberger, Dirk Jäger, Thomas Lindner, Walter Mier, Frederik Giesel, Uwe Haberkorn, Manuel Röhrich Abstract: Radiopharmaceutical therapies (RPTs) based on fibroblast activation protein (FAP) and [...]
![Impact of fat intake on [18F]AIF-NOTA-FAPI-04 uptake in normal abdominal organs](https://sofie.com/wp-content/uploads/2024/12/thumbnail-small.jpg)
Impact of fat intake on [18F]AIF-NOTA-FAPI-04 uptake in normal abdominal organs
Jiashun Dai, Wanjing Zhou, Huaping Liu, Chengzhi Jiang, Hui Ye Abstract: Purpose: [18F]AlF-NOTA-FAPI-04 demonstrates significant physiological uptake in the gallbladder and biliary tract system, representing a limitation of this positron emission tomography (PET) tracer. The aim of this study was to evaluate the impact [...]