Weizhi Xu, Jiayu Cai, Tianxing Peng, Tinghua Meng, Yizhen Pang, Long Sun, Hua Wu, Jingjing Zhang, Xiaoyuan Chen and Haojun Chen Abstract Fibroblast activation protein is overexpressed in the stroma of several cancer types. 18F-fibroblast activation protein inhibitor (FAPI)–74 is a PET tracer with [...]

Emil Novruzov1, Frederik L Giesel1,2, Yuriko Mori1, Peter L Choyke3, Mardjan Dabir1, Eduards Mamlins1, Dominik Schmitt1, Christina Antke1, Claudio Pinto4, Cristian Soza-Ried5,6, Rene Fernandez5, Horacio Amaral5,6, Vasko Kramer5,6, Leonardo Badinez7 Abstract Background: Radiolabeled fibroblast activation protein (FAP) ligands, a novel class of tracers for PET/CT [...]

Meiqi Wu1, Yanyu Wang2, Qiao Yang1, Xuezhu Wang1, Xu Yang2, Haiqun Xing1, Xinting Sang2, Xiang Li3, Haitao Zhao2, Li Huo4 Abstract Fibroblast activation protein contributes to immunosuppression and resistance to immunotherapies. This study aimed to compare baseline 68Ga-labeled fibroblast activation protein inhibitor (68Ga-FAPI) PET/CT and 18F-FDG [...]

Alessio Rizzo1, Manuela Racca1, Federico Garrou2, Elisabetta Fenocchio3, Luca Pellegrino4, Domenico Albano5, Francesco Dondi5, Francesco Bertagna5, Salvatore Annunziata6, Giorgio Treglia7,8,9 Abstract Various papers have introduced the use of positron emission tomography (PET) with [68Ga]Ga-radiolabeled fibroblast-activation protein inhibitor (FAPi) radiopharmaceuticals in different subtypes of gastric [...]

Yuriko Mori 1, Katharina Dendl 1, Jens Cardinale 1, Clemens Kratochwil 1, Frederik L Giesel # 1, Uwe Haberkorn # 1 Abstract Gallium 68 (68Ga)-labeled fibroblast activation protein (FAP) inhibitor (FAPI) PET is based on the molecular targeting of the FAP, which is known to be highly expressed in the major cell population in tumor stroma, termed [...]

Tristan T Demmert 1, Ines Maric 1, Kelsey L Pomykala 2, Katharina Lueckerath 1, Jens Siveke 3, Benedikt M Schaarschmidt 4, Rainer Hamacher 3, Ken Herrmann 1, Wolfgang P Fendler 1 Abstract In the setting of ongoing SARS-CoV-2 vaccination, vaccine-related tracer uptake in locoregional lymph nodes has become a well-known issue in tumor staging by 18F-FDG PET/CT. 68Ga-FAPI PET/CT is a new oncologic [...]

Philipp Backhaus 1, Matthias C Burg 2, Inga Asmus 1, Michaela Pixberg 1, Florian Büther 1, Hans-Jörg Breyholz 1, Randy Yeh 3, Stefanie B Weigel 2, Patricia Stichling 2, Walter Heindel 2, Stefanie Bobe 4, Peter Barth 5, Joke Tio 6, Michael Schäfers 1 Abstract Rationale: Improving imaging-based response following neoadjuvant chemotherapy (NAC) in breast cancer assessment could obviate the need for histologic confirmation of pathological complete response (pCR) and facilitate de-escalation [...]

Mahnoosh Naeimi 1, Peter L Choyke 2, Katharina Dendl 1, Yuriko Mori 3, Fabian Staudinger 1, Tadashi Watabe 4, Stefan A Koerber 5, Manuel Röhrich 1, Juergen Debus 5, Clemens Kratochwil 1, Uwe A Haberkorn 1, Frederik L Giesel 1 Abstract Purpose: A growing family of 68Ga-FAPI Positron Emission Tomography (PET) probes have shown promise in imaging a variety of medical conditions. 68Ga-FAPI-46 in particular has emerged as unique for [...]

Iris K Lee, Estela Noguera-Ortega, Zebin Xiao, Leslie Todd, John Scholler, Decheng Song, Maria Liousia, Katheryn Lohith, Kexiang Xu, Kimberly J Edwards, Michael D Farwell, Carl H June, Steven M Albelda, Ellen Pure, Mark A Sellmyer Abstract Purpose: Despite the success of chimeric antigen [...]

Ammar Alfteimi, Ulf Lützen, Alexander Helm, Michael Jüptner, Marlies Marx, Yi Zhao, Maaz Zuhayra Abstract Background: The recent development of quinoline-based radiotracers, which act as fibroblast activation protein inhibitors (FAPIs), has shown promising preclinical and clinical advantages. [68Ga]Ga-FAPI-46 is a new radiotracer for in [...]