Publications
Ensuring enantiomeric consistency in FAPI radiopharmaceuticals: comparative analysis of (S)- and (S/R)-FAPI-46/-74 confirms pharmacological equivalence GalleryEnsuring enantiomeric consistency in FAPI radiopharmaceuticals: comparative analysis of (S)- and (S/R)-FAPI-46/-74 confirms pharmacological equivalence
Ensuring enantiomeric consistency in FAPI radiopharmaceuticals: comparative analysis of (S)- and (S/R)-FAPI-46/-74 confirms pharmacological equivalence
Magdalena Staniszewska, Ralph Hübner, Camilla Locatelli, Douglas Howard, Matilde Forni, Francis Man, Bent Wilhelm Schoultz, Syed Nuruddin, Ingrid Sofie Norberg-Schulz Hagen, Sherly Mosessian, Ken Herrmann, Valeska von Kiedrowski, Katharina Lückerath Abstract: Background: Enantiomeric composition may impact binding and potentially performance of a drug product but [...]
90Y-FAPI-46 Radiopharmaceutical Therapy in Sarcoma and Other Solid Tumors: An Updated Cohort Analysis
Helena Lanzafame, Ilektra A. Mavroeidi, Kim M. Pabst, Pedro Fragoso Costa, Martin Schuler, Sebastian Bauer, Jens Kurth, Martin Heuschkel, Jens T. Siveke, Ken Herrmann, Karina Kostbade, David Kersting, Stephan Leyser, Stefan Fröhling, Christoph E. Heilig, Rainer Hamacher and Wolfgang P. Fendler Abstract: Fibroblast activation [...]
Revealing Reliability and Practicability of FAP-RADS Version 1.0 for Structured Reporting of FAPI Imaging in Pulmonary and Urothelial Carcinoma
Emil Novruzov, Eduards Mamlins, Liam Widjaja, Sophie C Siegmund, Tadashi Watabe, Yuriko Mori, Christian Stief, Amanda Tufman, Ken Herrmann, Michael A Gorin, Martin G Pomper, Steven P Rowe, Frederik L Giesel, Rudolf A Werner, Gabriel T Sheikh Abstract: Recently, a collaborative effort among research [...]
![FAP Expression in Renal Tumors Assessed by [68Ga]Ga-FAPI-46 PET Imaging and FAP Immunohistochemistry: A Case Series of Six Patients from the Prospective Exploratory Trial NCT04147494](https://sofie.com/wp-content/uploads/2025/12/info.ibamolecular-scaled.jpg)
FAP Expression in Renal Tumors Assessed by [68Ga]Ga-FAPI-46 PET Imaging and FAP Immunohistochemistry: A Case Series of Six Patients
Adrien Holzgreve, Lena M Unterrainer, Kimberly Flores, Ethan C Lam, Christine E Mona, Johannes Czernin, Brian M Shuch, Anthony E Sisk Jr, Jeremie Calais Abstract: Fibroblast activation protein (FAP) has been proposed as a pan-tumor target for PET imaging using FAP-targeted tracers. Here, we [...]
68Ga-FAPI PET/CT Prevents Futile Surgery and Demonstrates Tumor Biology in Patients with Pancreatic Ductal Adenocarcinoma
William McGahan, Alexa Chadwick, Karen Lindsay, Brook Gulhane, Melissa J Latter, Thomas O'Rourke, Paul A Thomas, David Cavallucci Abstract: PET/CT using 68Ga-labeled fibroblast activation protein inhibitor (68Ga-FAPI) may detect occult metastases and identify aggressive tumor biology in patients with pancreatic ductal adenocarcinoma (PDAC). We evaluated [...]
Revealing the hidden: A systematic review and meta-analysis of FAPI-based tracers imaging for brain metastatic lesions
Sajjad Sadeghpour, Atena Aghaee, Hojjat Ahmadzadehfar, Alessio Rizzo, Giorgio Treglia, Ramin Sadeghi Abstract: Background: Regarding the assessment of brain metastatic lesions, [18F]FDG PET/CT encounters challenges due to heightened physiological uptake in normal brain tissue, resulting in poor tumor-to-background ratios (TBR). Detecting brain metastases accurately has [...]