Johannes Toms 1, Jürgen Kogler 1, Simone Maschauer 1, Christoph Daniel 2, Christian Schmidkonz 3, Torsten Kuwert 3, Olaf Prante 4 3 Fibroblast activation protein (FAP) has emerged as an interesting molecular target used in the imaging and therapy of various types of cancers. 68Ga-labeled chelator-linked FAP inhibitors (FAPIs) have been successfully applied to PET imaging of various tumor [...]

Christian Schmidkonz 1, Simon Rauber 2, Armin Atzinger 1, Rahul Agarwal 2, Theresa Ida Götz 1, Alina Soare 2, Michael Cordes 1, Olaf Prante 1, Christina Bergmann 2, Arnd Kleyer 2, Philipp Ritt 1, Simone Maschauer 1, Peter Hennig 1, Johannes Toms 1, Markus Köhner 1, Bernhard Manger 2, John H Stone 3, Uwe Haberkorn 4, Tobias Baeuerle 5, Jörg H W Distler 2, Abbas Agaimy 6, Torsten Kuwert 1, Georg Schett 2, Andreas Ramming 7 Objectives: To date, there is no valuable tool to assess fibrotic disease activity in humans in [...]

Patrick Conen 1 2, Felix M Mottaghy 3 4 5 Purpose: Cancer-associated fibroblasts (CAFs) expressing fibroblast activation protein (FAP) have been associated with the aggressive nature of head and neck cancers (HNCs). These tumours grow diffusely, leading to extremely challenging differentiation between tumour and healthy tissue. This analysis aims to introduce [...]

Liang Zhao 1, Jianwei Gu 2, Kaili Fu 1, Qin Lin 1, Haojun Chen 2 Abstract: Ga-FAPI PET/CT was performed in a 56-year-old cirrhotic patient with multiple liver nodules, which were suspected of hepatocellular carcinoma by contrast-enhanced magnetic resonance but were not visualized by F-FDG PET/CT. Increased Ga-FAPI liver uptake was observed in [...]

Jieling Zheng 1, Shaobo Yao 2 Article available for purchase or this subscription. Affiliations: Department of Nuclear Medicine, The First Affliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Fuzhou, 350005, Fujian Province, China. Department of Nuclear Medicine, The First Affliated Hospital of Fujian Medical University, [...]

Haojun Chen1, Yizhen Pang1, Jingxun Wu2, Liang Zhao3, Bing Hao1, Jing Wu1, Jihong Wei1, Siming Wu1, Long Zhao1, Zuoming Luo1, Xuehua Lin1, Chengrong Xie4, Long Sun5, Qin Lin6, Hua Wu7 Purpose: We evaluated the potential usefulness of [68Ga]Ga-DOTA-FAPI-04 positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various types of cancer, compared with [18F] [...]