Liang Zhao 1Jianwei Gu 2Kaili Fu 1Qin Lin 1Haojun Chen 2

Abstract: Ga-FAPI PET/CT was performed in a 56-year-old cirrhotic patient with multiple liver nodules, which were suspected of hepatocellular carcinoma by contrast-enhanced magnetic resonance but were not visualized by F-FDG PET/CT. Increased Ga-FAPI liver uptake was observed in this cirrhotic patient. However, the nodules had no pathological Ga-FAPI uptake and were clearly visualized due to the low activity compared with surrounding liver parenchyma. The Ga-FAPI PET/CT features, suggestive of benign nodules, have been later confirmed by histopathological examination. This case suggested that Ga-FAPI PET/CT may be useful in the differentiation between benign nodules and hepatocellular carcinoma in the patient with liver cirrhosis.


  1. From the Departments of Radiation Oncology.
  2. Nuclear Medicine and Minnan PET Center, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen, China.