ELIXYS is an automated radiochemical synthesizer for the production of preclinical and clinical PET probes.
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- It’s a hybrid.
ELIXYS is a single platform solution for R&D and production. Build new syntheses from scratch, and then routinely perform your optimized protocol. It’s the best of flexible and fixed systems, without painful re-plumbing to move between syntheses.
- It’s a triple threat.
ELIXYS is the first of its kind – a fully integrated, three–reactor radiosynthesizer. We designed it to meet the challenging, multi–pot synthesis conditions of [18F]FAC, but you can also use it to perform three, one–pot syntheses back–to–back–to–back. For the same cost as a single reactor system, we think ELIXYS is the better choice for limited space and resources.
- It’s easy to use. Honestly.
Even with all that firepower, ELIXYS is everyone’s instrument. We’ve spent a lot of time in the details: reduction of tubing and valves, intuitive, chemist–friendly software, and disposable cassettes that are simple to load and remove. From the most seasoned radiochemist to brand new technicians, ELIXYS is easy to learn and operate.
Three identical, independent, moveable reactors give you the ability to perform diverse 1, 2, and 3 pot syntheses with intermediate and final purification. Perform fully sealed reactions at higher temperatures (200C) and pressures (>150 psi) than any vial-based synthesizer without loss of product. Visually monitor evaporations with reactor vial cameras. Track between-reactor transfers with radiation detectors. No need to customize or re-plumb the hardware to move between syntheses.
Reagent Delivery Robot + Disposable Cassettes
Who says robots are for biological instrumentation only? We love our liquid handlers, and decided to borrow that design when thinking about reagent delivery on demand. On ELIXYS, your reagents stay sealed and safe from air and moisture until just before addition. Disposable cassettes provide housing for all wetted paths, and can be cleaned and reused for probe development and optimization, or discarded after routine production runs.
We think you should spend your valuable time modifying the chemistry, not the synthesizer. Our software features a drag–and–drop, unit operation–based interface. With administrative controls, user defined pre–synthesis checklists and batch records, and real–time video and state monitoring, ELIXYS is ready for both the preclinical and cGMP environments.
PURE/FORM is the newest member of the ELIXYS suite of products. A compact module designed to be used inline with the FLEX/CHEM radiosynthesizer, PURE/FORM provides seamless, automated purification and formulation post-synthesis, all controlled with our user-friendly ELIXYS software.
PURE/FORMA companion purification and formulation module
Measuring just under 20 cm (8 inches) in width, PURE/FORM delivers new capabilities to the ELIXYS platform in a small footprint. The module interfaces with your existing ELIXYS system, with zero hardware or facility modifications required. PURE/FORM is a premium instrument for your diverse synthesis needs. Features include:
- 4-channel gradient HPLC pump
- Fully integrated UV and radiation detectors
- Multiple fraction-collection positions to streamline method development
- Integrated syringe pump to accurately drive probe formulation via solid-phase extraction
- Automated sterile filtration of final probe
PURE/FORM’s controls are fully integrated into the existing ELIXYS software package. Two new unit operations have been added, allowing PURE/FORM functionality to be accessed through our novel drag-and-drop interface and simply added to your existing sequences.
Our software was designed for chemists, not coders, and enables precise monitoring and control over the entire purification and formulation processes. Control fluid paths, hide detector outputs, or program the HPLC pump with ease. Interact with all graphs using smartphone-like features: finger scrolling, pinch zoom, and doubletap auto scaling. After a sequence has finished, use the Analysis screen to calculate peak areas and retention times. Easily export your data as a spreadsheet to generate figures for your next publication.
To date, we’ve synthesized:
SOFIE–optimized protocols are available with every ELIXYS purchase.
Check back for a list of reagent kits coming soon!